THURSDAY, May 30 (HealthDay News) ? Patients with advanced heart failure have much better survival odds today than 20 years ago, but one in three still dies within three years of their diagnosis, researchers report.
?We are doing a good job of ensuring that patients receive the latest therapies for heart failure, but we still have a lot more work to do,? study senior author Dr. Tamara Horwich, an assistant professor of cardiology at the University of California, Los Angeles, David Geffen School of Medicine, said in a UCLA news release.
?It is very sobering that despite recent improvements, a third of advanced heart-failure patients aren?t surviving past three years,? Horwich added.
In people with heart failure, the heart can?t effectively pump blood to the rest of the body. The increasingly common condition affects almost 6 million people in the United States.
For the study, published in the May issue of Circulation: Heart Failure, the researchers examined outcomes in more than 2,500 adults diagnosed with ?heart failure with reduced ejection fraction,? which is characterized by a weak heart muscle.
The patients were divided into three groups based on when they were treated: 1993 through 1998; 1999 through 2004; and 2005 through 2010. The researchers followed the patients for three years after they were diagnosed.
The study revealed dramatic differences. Patients treated from 1999 on were more likely to receive life-extending drugs, such as beta-blockers and aldosterone antagonists, as well as devices to help stabilize irregular heart rhythms, such as implantable cardioverter defibrillators. Whereas just 15.5 percent of patients used beta-blockers from 1993 to 1998, more than 87 percent used them between 2005 and 2010, the study pointed out.
The increased use of these treatments coincided with publication of the results of clinical trials, and the development of treatment guidelines, the researchers noted.
Prevalence of sudden cardiac death has also decreased, the study showed. At the three-year follow-up point, sudden death declined from 10.1 percent between 1993 and 1998 to 4.6 percent between 2005 and 2010.
Overall mortality rates also decreased over the course of the study. After taking risk factors such as age and gender into account, the investigators found that patients treated between 2005 and 2010 were 42 percent less likely than those in the earliest treatment group to die from any cause.
People who may have died suddenly in the past are living longer thanks to widespread use of implantable cardioverter defibrillators, the authors noted. This trend may be one reason why a shift occurred in the manner of death over the course of the study.
The researchers found patient mortality from progressive heart failure increased from 11.6 percent between 1993 and 1998 to nearly 20 percent between 2005 and 2010. The need for emergency heart transplants also increased over time.
Many of those patients would have died sooner in the earlier eras, said study author Dr. Gregg Fonarow, a UCLA professor of cardiovascular medicine and science.
?For patients with the most advanced heart failure, treatment options used to be limited to heart transplantation ? or face early death,? Fonarow said in the news release.
?This study demonstrates that with improvements in medical therapy and availability of implanted devices, survival for these patients has improved considerably. What was once considered an end-stage, terminal disease state has, through implementation of innovative treatments, evolved into a manageable, but still challenging, condition,? he explained.
However, more studies are still needed to explore new treatments for heart failure patients, the researchers added.
More information
The U.S. National Heart, Lung, and Blood Institute has more about heart failure.
Climate change threatens extinction for 82 percent of California native fishPublic release date: 30-May-2013 [ | E-mail | Share ]
Contact: Peter Moyle pbmoyle@ucdavis.edu 530-752-6355 University of California - Davis
Top 20 native California fish at risk of extinction from climate change
Salmon and other native freshwater fish in California will likely become extinct within the next century due to climate change if current trends continue, ceding their habitats to non-native fish, predicts a study by scientists from the Center for Watershed Sciences at the University of California, Davis.
The study, published online in May in the journal PLOS ONE, assessed how vulnerable each freshwater species in California is to climate change and estimated the likelihood that those species would become extinct in 100 years.
The researchers found that, of 121 native fish species, 82 percent are likely to be driven to extinction or very low numbers as climate change speeds the decline of already depleted populations. In contrast, only 19 percent of the 50 non-native fish species in the state face a similar risk of extinction.
"If present trends continue, much of the unique California fish fauna will disappear and be replaced by alien fishes, such as carp, largemouth bass, fathead minnows and green sunfish," said Peter Moyle, a professor of fish biology at UC Davis who has been documenting the biology and status of California fish for the past 40 years.
"Disappearing fish will include not only obscure species of minnows, suckers and pupfishes, but also coho salmon, most runs of steelhead trout and Chinook salmon, and Sacramento perch," Moyle said.
Fish requiring cold water, such as salmon and trout, are particularly likely to go extinct, the study said. However, non-native fish species are expected to thrive, although some will lose their aquatic habitats during severe droughts and low-flow summer months.
The top 20 native California fish most likely to become extinct in California within 100 years as the result of climate change include (asterisks denote a species already listed as threatened or endangered):
Klamath Mountains Province summer steelhead
McCloud River redband trout
Unarmored threespine stickleback*
Shay Creek stickleback
Delta smelt*
Long Valley speckled dace
Central Valley late fall Chinook salmon
Kern River rainbow trout
Shoshone pupfish
Razorback sucker*
Upper Klamath-Trinity spring Chinook salmon
Southern steelhead*
Clear Lake hitch
Owens speckled dace
Northern California coast summer steelhead
Amargosa Canyon speckled dace
Central coast coho salmon*
Southern Oregon Northern California coast coho salmon*
Modoc sucker*
Pink salmon
The species are listed in order of vulnerability to extinction, with No. 1 being the most vulnerable.
Climate change and human-caused degradation of aquatic habitats is causing worldwide declines in freshwater fishes, especially in regions with arid or Mediterranean climates, the study said. These declines pose a major conservation challenge. However, there has been little research in the scientific literature related to the status of most fish species, particularly native ones of little economic value.
Moyle saw the need for a rapid and repeatable method to determine the climate change vulnerability of different species. He expects the method presented in the study to be useful for conservation planning.
"These fish are part of the endemic flora and fauna that makes California such a special place," said Moyle. "As we lose these fishes, we lose their environments and are much poorer for it."
###
Co-authors on the study were postdoctoral students Joseph Kiernan, Patrick Crain and Rebecca Quiones of the Center for Watershed Sciences at UC Davis.
Funding for the study was provided by the California Energy Resources Conservation and Development Commission Instream Flow Assessment Program.
Read the study: http://bit.ly/1549Fr8
About UC Davis
For more than 100 years, UC Davis has engaged in teaching, research and public service that matter to California and transform the world. Located close to the state capital, UC Davis has more than 33,000 students, more than 2,500 faculty and more than 21,000 staff, an annual research budget of nearly $750 million, a comprehensive health system and 13 specialized research centers. The university offers interdisciplinary graduate study and more than 100 undergraduate majors in four colleges Agricultural and Environmental Sciences, Biological Sciences, Engineering, and Letters and Science. It also houses six professional schools Education, Law, Management, Medicine, Veterinary Medicine and the Betty Irene Moore School of Nursing.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Climate change threatens extinction for 82 percent of California native fishPublic release date: 30-May-2013 [ | E-mail | Share ]
Contact: Peter Moyle pbmoyle@ucdavis.edu 530-752-6355 University of California - Davis
Top 20 native California fish at risk of extinction from climate change
Salmon and other native freshwater fish in California will likely become extinct within the next century due to climate change if current trends continue, ceding their habitats to non-native fish, predicts a study by scientists from the Center for Watershed Sciences at the University of California, Davis.
The study, published online in May in the journal PLOS ONE, assessed how vulnerable each freshwater species in California is to climate change and estimated the likelihood that those species would become extinct in 100 years.
The researchers found that, of 121 native fish species, 82 percent are likely to be driven to extinction or very low numbers as climate change speeds the decline of already depleted populations. In contrast, only 19 percent of the 50 non-native fish species in the state face a similar risk of extinction.
"If present trends continue, much of the unique California fish fauna will disappear and be replaced by alien fishes, such as carp, largemouth bass, fathead minnows and green sunfish," said Peter Moyle, a professor of fish biology at UC Davis who has been documenting the biology and status of California fish for the past 40 years.
"Disappearing fish will include not only obscure species of minnows, suckers and pupfishes, but also coho salmon, most runs of steelhead trout and Chinook salmon, and Sacramento perch," Moyle said.
Fish requiring cold water, such as salmon and trout, are particularly likely to go extinct, the study said. However, non-native fish species are expected to thrive, although some will lose their aquatic habitats during severe droughts and low-flow summer months.
The top 20 native California fish most likely to become extinct in California within 100 years as the result of climate change include (asterisks denote a species already listed as threatened or endangered):
Klamath Mountains Province summer steelhead
McCloud River redband trout
Unarmored threespine stickleback*
Shay Creek stickleback
Delta smelt*
Long Valley speckled dace
Central Valley late fall Chinook salmon
Kern River rainbow trout
Shoshone pupfish
Razorback sucker*
Upper Klamath-Trinity spring Chinook salmon
Southern steelhead*
Clear Lake hitch
Owens speckled dace
Northern California coast summer steelhead
Amargosa Canyon speckled dace
Central coast coho salmon*
Southern Oregon Northern California coast coho salmon*
Modoc sucker*
Pink salmon
The species are listed in order of vulnerability to extinction, with No. 1 being the most vulnerable.
Climate change and human-caused degradation of aquatic habitats is causing worldwide declines in freshwater fishes, especially in regions with arid or Mediterranean climates, the study said. These declines pose a major conservation challenge. However, there has been little research in the scientific literature related to the status of most fish species, particularly native ones of little economic value.
Moyle saw the need for a rapid and repeatable method to determine the climate change vulnerability of different species. He expects the method presented in the study to be useful for conservation planning.
"These fish are part of the endemic flora and fauna that makes California such a special place," said Moyle. "As we lose these fishes, we lose their environments and are much poorer for it."
###
Co-authors on the study were postdoctoral students Joseph Kiernan, Patrick Crain and Rebecca Quiones of the Center for Watershed Sciences at UC Davis.
Funding for the study was provided by the California Energy Resources Conservation and Development Commission Instream Flow Assessment Program.
Read the study: http://bit.ly/1549Fr8
About UC Davis
For more than 100 years, UC Davis has engaged in teaching, research and public service that matter to California and transform the world. Located close to the state capital, UC Davis has more than 33,000 students, more than 2,500 faculty and more than 21,000 staff, an annual research budget of nearly $750 million, a comprehensive health system and 13 specialized research centers. The university offers interdisciplinary graduate study and more than 100 undergraduate majors in four colleges Agricultural and Environmental Sciences, Biological Sciences, Engineering, and Letters and Science. It also houses six professional schools Education, Law, Management, Medicine, Veterinary Medicine and the Betty Irene Moore School of Nursing.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Mike "Sugar Bear" Thompson from "Here Comes Honey Boo Boo."
It's a tough time for the family from TLC's hit series, "Here Comes Honey Boo Boo." Over the past few days, they've weathered a mysterious health emergency and the loss of a beloved pet.
The woes started last Friday evening, when dad Mike "Sugar Bear" Thompson collapsed and was taken to the hospital. According to posts on the official Honey Boo Boo Facebook fan page, which is run by "Mama" June Shannon and a family friend, Sugar Bear underwent "a lot of tests on his brain" and the family feared it could be "very serious." Recent posts on both their Facebook and Twitter accounts added the hashtag "#prayforsugarbear."
But in the midst of the crisis, things got even worse for the reality TV stars from McIntyre, Ga.
While Thompson remained at the hospital, they discovered that the family dog, a Chihuahua named China they'd rescued six years earlier, had been "hit and left to die."
"(She was) still spasming as they found her," one Facebook post explained. "We think it may have been done intentionally cause of where she was found."
As for Thompson, the latest updates indicate there's been no change in his condition. The cause of his collapse is still a mystery.
The incident is just the latest in a long list of medical emergencies for the family patriarch in recent months. Last September, he was hospitalized due to a foot infection following a "mud-boggin'" accident. Then, in December, an ambulance was called after he fell ill during a toy drive. And just three months ago, he was hospitalized again after a bout of pancreatitis.
TODAY.com reached out to TLC about the family's troubles. The network had no comment.
"Here Comes Honey Boo Boo" returns with new episodes starting July 17.
On this quiet Monday, Samsung decided to do a little teaser for its upcoming "Premiere 2013" roadshow event in London on June 20th. The above poster only mentions "Galaxy & ATIV," which suggest the event will mainly feature Android and Windows-based devices. The remaining tiles show partial shots of three mysterious devices -- possibly a tablet or phone, a convertible laptop (à la Sony VAIO Duo 11) and a camera (maybe the rumored Galaxy S 4 Zoom?). Obviously, we'll be at the event to solve this mystery, so stay tuned for more.
MOSCOW (AP) ? A senior Russian diplomat says Washington's latest moves aimed at easing Moscow's concern about NATO's U.S.-led missile defense plans are insufficient.
Monday's statement by Deputy Foreign Minister Sergei Ryabkov followed an exchange of letters by President Barack Obama and Russia's President Vladimir Putin that mentioned the missile defense dispute, a longtime irritant in bilateral ties. Russian media said Obama offered to provide Russia with more information about the missile defense plans.
The Kremlin has dismissed U.S. assurances that the shield is a defense against Iranian missiles and sought legally binding guarantees that it wouldn't be aimed against Russia.
Ryabkov told Voice of Russia radio that the latest U.S. proposals on missile defense are "concrete" and "serious," but Moscow still sees them as insufficient and wants more specific technical guarantees.
ZINTAN, Libya (AP) ? Wearing a sky-blue safari suit and a pair of sandals, the imprisoned son of slain dictator Moammar Gadhafi made his second court appearance this year on Thursday in a local court in Libya's western mountains where he is facing charges of harming state security.
Jailed in the town of Zintan, whose fighters captured him as he was fleeing to neighboring Niger, the trial of Seif al-Islam Gadhafi underlines Libya's ongoing state of lawlessness and lacking state authority in the face of a hodgepodge of militia groups.
With no national army or police in place since the fall of Gadhafi's regime in an eight-month civil war in 2011, successive governments have been too weak to either secure Seif al-Islam's imprisonment in the capital, Tripoli, or put pressure on his captors, a militia known as Abu Bakr al-Sadek, to hand him over to the central government.
The trial also comes at a time when the Libyan capital is locked in turmoil as militia groups blockaded, for a fifth day, the foreign and justice ministries, and stormed the interior ministry and state TV buildings. They want the country's parliament to pass a contentious law that would exclude Gadhafi-era officials from political life.
One version of the law, if passed, would dismiss a considerable slice of Libya's new rulers, who served under Gadhafi in the 1980s ? regardless of their role during the early days of the uprising in 2011 that ended with the dictator's death in his hometown of Sirte.
Some rights activists decried the law as too harsh. Others see a purge of former Gadhafi-era officials as a necessary prerequisite to transitional justice and national reconciliation.
The rule of law is still beyond reach in the North African country, which for 42 years was governed by the dictator's whims and eccentricities. Courts are still paralyzed and security remains tenuous as unruly militias proliferate.
On Thursday, courts in the southern city of Sabha partially suspended work and judges and court employees held a sit-in to protest severe deterioration of security after recurrent prison breaks. Most recently, 111 prisoners escaped on Tuesday from Sabha main prison, according to Mohammed Farag Ibrahim, Sabha prosecutor.
Gomaa Nasr, the head of the prison, told the state news agency LANA that the prison break was not the first and that during recent months hundreds of prisoners had escaped from poorly secured prison facilities.
After the ministries were surrounded, pro-democracy activists urged the government to disarm and disband the militias and held protests denouncing the armed groups. However, a Thursday demonstration in Tripoli's Algeria Square saw low turnout, reflecting waning enthusiasm or fear among local residents.
The state, however, relies heavily on militias to serve as security forces since the police and military remain a shambles. The government pays the salaries of tens of thousands of militiamen who often pursue their own agendas ? enforcing their own rule over neighborhoods and towns, engaging in kidnappings and extortion and fighting gun battles with rival militias. Some have hard-line Islamist ideologies and have become notorious for imposing strict interpretations of Islamic law.
With many fearing the situation will worsen, Zintan's fighters have felt encouraged to keep Seif al-Islam away from the capital.
"There is zero control in the capital," said town council spokesman Khaled al-Zintani. "Weapons are in everyone's hands and prison breaks are recurrent. Zintan is the safest place," he said, adding that the trial would be open to journalists and human rights groups.
While he insisted Seif al-Islam could be transferred to Tripoli if the government secured the area and requested it, he claimed that Seif al-Islam's life is under threat.
"There are parties who want to silence him because if he talked he will reveal the information that would stain them and would uncover corruption of those who cooperated with the regime at the last decade."
At Thursday's 15-minute court session, Gadhafi's longtime heir apparent seemed at times apathetic, smiling occasionally and revealing a missing front tooth as the judge adjourned the hearing until Sept. 19 to allow defense lawyers time to study the case. It was unclear how he lost the tooth.
The 40-year-old is the most heavyweight former regime member to be tried in Libya. Imprisoned in solitary confinement, according to al-Zintani, Seif al-Islam has spoken few words during his two court appearances.
"Fine," Seif al-Islam said derisively when the judge told him that two volunteer lawyers would be his defense team.
Seif al-Islam also is facing charges of attempting to escape prison and insulting Libya's new flag. The charges are linked to his June meeting with an International Criminal Court delegation accused of smuggling documents and a camera to him in his cell. The four-member team was detained by Zintan rebels but released after the ICC made an apology and pledged to investigate the incident.
The charges are separate from those by the International Criminal Court, which indicted Seif al-Islam for the murder and persecution of protesters in the uprising that ultimately toppled his father's regime in 2011.
According to filings by defense lawyers at the ICC, Seif al-Islam said he wants to be tried for alleged war crimes in the Netherlands, claiming that a trial in Libya would be tantamount to murder. "There will certainly be no justice in the case if the prosecution is based on evidence from torture," he said. "I am not afraid to die, but if you execute me after such a trial, you should just call it murder," he added.
The rest of Seif al-Islam's family, including his mother, his sister, two brothers and others, were granted asylum in Oman in March, moving there from Algeria, where they found refuge during the civil war.
WASHINGTON (AP) ? The number of Americans seeking unemployment aid fell last week to seasonally adjusted 324,000, the lowest since January 2008. The drop points to fewer layoffs and possibly more hiring.
The Labor Department said Thursday that weekly applications fell 18,000, the second straight sharp drop. The four-week average, a less volatile measure, plummeted 16,000 to 342,250, close to a five-year low.
Applications are a proxy for layoffs. When they fall below 350,000, it is generally consistent with moderate hiring.
But layoffs are only half the equation: Companies also need to be confident enough to add workers for job growth to pick up and lower the unemployment rate. Many have held off adding new workers in recent months, possibly because of concerns about the impact of federal spending cuts and tax increases.
Economists forecast that the economy added 160,000 jobs last month. That's much better than the 88,000 added in March, but below last year's pace of nearly 185,000 per month. The unemployment rate is expected to remain unchanged at 7.6 percent.
But many have lowered their estimates this week, some as low as 120,000, after several reports suggested that slower growth is dragging down hiring. The government will release the April employment report Friday.
The spending cuts, known as sequestration, and higher Social Security taxes may be making businesses more cautious about hiring. And the tax increase could slow consumer spending. The Federal Reserve said Wednesday that those policies are "restraining economic growth."
"We think hiring will be more subdued in the second quarter as the economy weathers a consumer spending slowdown and sequestration job cuts," said Julia Coronado, an economist at BNP Paribas. Unemployment benefit applications "will not capture either of these developments." One reason layoffs may not rise is that federal agencies are cutting hours, rather than jobs.
The data ahead of Friday's jobs report have been discouraging. On Wednesday, payroll provider ADP said companies added just 119,000 jobs in April. And a survey of manufacturers by the Institute for Supply Management found that a measure of employment fell sharply last month.
Many companies have been advertising more jobs but have been slow to fill them. Job openings jumped 11 percent during the 12 months that ended in February, but the number of people hired declined, according to a Labor Department report last month.
Nearly 5 million people received unemployment aid during the week ended April 13, the latest data available. That's down from nearly 5.1 million in the previous week.
Still, consumers are more optimistic that the job market is healing and will deliver higher pay later this year, according to a survey of April consumer confidence released this week. And lower gas prices could offset some of the pinch from the tax increase.
The economy grew at an annual rate of 2.5 percent from January through March, the government said last week. That was an improvement from the anemic growth of 0.4 percent in the final three months of last year. Most economists expect growth will slow in the current quarter to 2 percent or lower.
Activision on Wednesday announced that the latest installment of its best-selling Call of Duty franchise, called Call of Duty: Ghost, will launch later this year on the Xbox 360, PlayStation 3, PC and ?next generation platforms.? The latest Call of Duty game is being developed by Infinity Ward, the studio behind the original Call of Duty and the critically acclaimed Call of Duty: Modern Warfare series. Activision?s first-person shooter has consistently shattered game sale records year after year and its latest installment is expected to continue this trend. Call of Duty: Ghost is scheduled to be released on November 5th. Starting today, fans can pre-order the game at retail stores. Activision?s press release follows below.
ACTIVISION ANNOUNCES THE NEXT GENERATION OF CALL OF DUTY? WITH CALL OF DUTY?: GHOSTS
[More from BGR: HTC One seen holding its own against Galaxy S4 marketing barrage]
Call of Duty: Ghosts will set a new Benchmark for the Next Generation
All-New World, Story, Characters and Experience, All Powered by New, Next Gen Call of Duty Engine from the Developer that started it all, Infinity Ward
For an Exclusive First Look at the Game, Tune in to Xbox: The New Generation Revealed, May 21 at 10AM PDT on Xbox.com, Xbox Live or SPIKE TV
Groundbreaking Title Lands on November 5
Santa Monica, CA ? May 1, 2013 ? Prepare for the next generation of Call of Duty?. The franchise that has defined a generation of gaming is set to raise the bar once again with the all-new Call of Duty?: Ghosts. Published by Activision Publishing, Inc., a wholly owned subsidiary of Activision Blizzard (Nasdaq: ATVI), and developed by Infinity Ward, the studio that created the original Call of Duty and the seminal Call of Duty?: Modern Warfare? series, Call of Duty: Ghosts ushers in the next generation of the franchise. The new title delivers a riveting all-new gameplay experience built on an entirely new story, setting and cast of characters, all powered by a new, next generation Call of Duty engine that redefines the series for the next generation.
?Infinity Ward set the gold standard for first-person action for a generation, and they?re going to do it again with Call of Duty: Ghosts,? said Eric Hirshberg, CEO of Activision Publishing, Inc. ?Ghosts delivers an all-new story, all-new characters, an all-new Call of Duty world, all powered by a next generation Call of Duty engine, which is a leap forward for the franchise. Infinity Ward is going all-in to create the next generation of Call of Duty worthy of the world?s greatest fans.?
?Everyone was expecting us to make Modern Warfare 4, which would have been the safe thing to do. But we?re not resting on our laurels,? said Mark Rubin, executive producer of developer Infinity Ward. ?We saw the console transition as the perfect opportunity to start a new chapter for Call of Duty. So we?re building a new sub-brand, a new engine, and a lot of new ideas and experiences for our players. We can?t wait to share them with our community.?
To see an exclusive first look at Call of Duty: Ghosts tune in to Xbox: the Next Generation Revealed on May 21 at 10AM PDT on Xbox.com, Xbox LIVE or SPIKE TV for the debut of the all-new game from Infinity Ward.
?We are consistently thrilled with the overwhelming response received from critics and consumers alike to the Call of Duty series, which has firmly established its home on the Xbox 360 with the game?s largest and most engaged community,? said Don Mattrick, president of the interactive entertainment business at Microsoft. ?With Call of Duty: Ghosts, we have no doubt that our longtime partners, Activision and Infinity Ward, will raise the bar higher than ever before for this incredible franchise.?
Starting today, fans can begin pre-ordering their copy of Call of Duty: Ghosts at retail outlets worldwide.
?There?s no other video game property like Call of Duty. It?s the biggest game franchise on the planet that has had some of the biggest game entertainment launches in history,? said Tony Bartel, president of GameStop. ?We are very excited for the launch of Call of Duty: Ghosts, as we transition to next generation consoles.?
Call of Duty: Ghosts will release on Xbox 360? video game and entertainment system from Microsoft, PlayStation?3 computer entertainment system and PC on November 5. Call of Duty: Ghosts will also be available for next generation platforms. For the latest intel, check out: http://www.callofduty.com/ghosts, http://www.facebook.com/CODGhosts, or follow on Twitter @InfinityWard. Call of Duty: Ghosts is not yet rated.
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Public release date: 30-May-2013
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